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Dosing & Administration

Well-Established Dosing Regimen

  • The recommended dose of EXTAVIA is 0.25 mg injected subcutaneously every other day1
  • Gradual dose titration during initiation of EXTAVIA may reduce flu-like symptoms1
    • Dose titration is not necessary in patients switched from Betaseron® (interferon beta-1b). These patients continue at their current dose1,2
  • EXTAVIA is the exact same molecule as Betaseron, and EXTAVIA 0.25 mg was approved by the FDA based on the same registration trials as Betaseron 0.25 mg1,2

Generally, patients should be started at 0.0625 mg (0.25 mL) subcutaneously every other day, and increased over a 6-week period to 0.25 mg (1 mL) every other day.1

Schedule for dose titration 1
Treatment Week Dose Volume
1-2 0.0625 mg 0.25 mL
3-4 0.125 mg 0.5 mL
5-6 0.1875 mg 0.75 mL
7+ 0.25 mg 1 mL
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References:
1. Extavia [Prescribing Information]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2016. 2. Betaseron [Prescribing Information]. Montville, NJ: Bayer HealthCare Pharmaceuticals Inc; 2016. 3. Kappos L, Polman CH, Freedman MS, et al. Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes. Neurology. 2006;67:1242-1249. 4. Fingertip Formulary®. Analytics report. Extavia: Percentage of covered lives. Accessed October 2017.