Learn about EXTAVIA's efficacy.

Your patients deserve an effective treatment for their multiple sclerosis. In clinically isolated syndrome (CIS), EXTAVIA is proven effective in delaying the second exacerbation of MS. See how your patients will benefit from EXTAVIA.

EXTAVIA: A therapy with proven efficacy.

Time to second exacerbation chart
Number of patients free from second exacerbation
n=175 129 115 101 24
n=292 249 225 205 47


Results from the Betaseron® (interferon beta-1b) BENEFIT Study, a 2-year, multicenter, randomized, double-blind, placebo-controlled trial in patients who had recently experienced an isolated demyelinating event suggestive of MS CIS. The primary end point was time to the development of a second clinical exacerbation. Secondary end points were brain MRI measures. Patients received either interferon beta-1b (0.25 mg every other day) or placebo (N=468).1

*By proportional hazards regression adjusted for age/sex/steroids/T2-lesions/Gd-lesions.3


of interferon beta-1b patients with clinically isolated syndrome (CIS) did not experience a second exacerbation at year 22


of patients randomized to interferon beta-1b completed the 2-year study2

EXTAVIA is effective in relapsing-remitting multiple sclerosis.

Annual exacerbation rate chart


Results from the Betaseron® IFNB Study, a 2-year, double-blind, multicenter, randomized, parallel placebo-controlled clinical trial in patients with relapsing-remitting multiple sclerosis (RRMS). Patients were randomized to interferon beta-1b (0.05 mg every other day), interferon beta-1b (0.25 mg every other day), or placebo. Results shown here compare the interferon beta-1b 0.25 mg arm with the placebo arm. The primary end points were the frequency of exacerbations per patient and the proportion of exacerbation-free patients. A number of secondary clinical and MRI measures were also employed, including prolongation of median time to first exacerbation (N=372).1


reduction in annualized exacerbation rate1 (p=0.0001)


of patients taking interferon beta-1b 0.25 mg remained exacerbation free vs 16% of placebo patients1 (p=0.094)

See the study results of interferon beta-1b 0.25 mg versus placebo.

51% reduction

in rate of moderate or severe exacerbations per year1 (p=0.001)

80% increase

in median time to first exacerbation1 (p=0.010)

75% reduction

of newly active MRI lesions3 (p=0.0026)

83% reduction

in median number of T2 active lesions3 (p=0.0089)

The exact relationship between MRI findings and the clinical status of patients is unknown. Changes in lesion area often do not correlate with changes in disability progression. The prognostic significance of the MRI findings in this study has not been evaluated.

Images are not actual physicians or patients.

References: 1. Extavia [Prescribing Information]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2021. 2. Betaseron [Prescribing Information]. Montville, NJ: Bayer HealthCare Pharmaceuticals Inc; 2016. 3. Kappos L, Polman CH, Freedman MS, et al. Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes. Neurology. 2006;67:1242-1249. 4. Fingertip Formulary®. Analytics report. Extavia: Percentage of covered lives. Accessed October 2019.